N154: Molecular Neurobiology is taught in the Spring Quarter by Professor Katumi Sumikawa.
N154 is an upper division class aimed at Biological Sciences and Neurobiology Majors. It requires N110 as a prerequisite course, and covers molecules involved in neuronal communication, the foundation for brain function, with particular emphasis on molecules involved in learning and memory. Specific goals of the course are to understand: (i) the control of synaptic transmission, (ii) the regulation of receptor expression, (iii) signaling pathways activated by neurotransmitters, (iv) the cellular mechanism underlying learning and memory.
No textbook is required, and class size is limited to a maximum of 30 students. Grades are determined by three exams.
Molecules involved in synaptic transmission
Synthesis, storage, and removal of neurotransmitters Neurotransmitter transporters and brain disorders
Synaptic transmission and drugs of abuse
Molecular markers for identification of specific neuron types Release of neurotransmitters
Molecules involved in neuronal signaling
Ligand-gated neurotransmitter receptors Regulation of receptor gene expression
G protein-coupled neurotransmitter receptors G proteins and effector proteins
Mechanisms underlying synaptic plasticity
Protein phosphorylation in neuronal signaling
Long-term potentiation, a cellular model of learning and memory Long-term depression
Exam 3 – Final Exam