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Gene regulatory architecture of Alzheimer’s disease
Dr. Vivek Swarup
Department of Neurobiology and Behavior
Date: Friday, October 21, 2022
** This is a hybrid event**
Abstract: Gene regulatory architecture of Alzheimer’s disease
The human brain changes at the molecular and cellular level with aging, and these molecular changes reflect either healthy or degenerative behavioral and cognitive function. Degeneration at the cognitive level, known as dementia, is seen in a large proportion of the population. Alzheimer’s disease (AD) is the most common dementia with a prevalence rate of 16% among individuals older than 65 years of age, which translates to total economic cost of about $290 billion/year. In this talk, we use a multi-omic approach to understand molecular changes in AD in an unbiased genome-wide manner. We then use systems biology and functional genomics approaches and intersect the data with orthogonal datasets to construct the molecular regulatory networks and identify the changes that lead to dementia. Our study uses state-of-the art single-nucleus transcriptomics/epigenetics and spatial transcriptomics to unravel novel disease biology and uncover gene-regulatory architecture of the disease.