Neurobiology and Behavior Seminar
Thursday, February 28th, 2019
11 AM, Dale Melbourne Herklotz Conference Center, Center for Neurobiology of Learning and Memory (Building 506 on the campus map)
Majid Mohajerani, PhD
University of Lethbridge
“Probing the spatiotemporal dynamics of hippocampal-cortical dialogue in health and Alzheimer’s disease”
In my talk, I will provide new information regarding the interaction of hippocampus (HPC) and neocortex (NC) during sleep. Although evidence indicates that episodic memories are formed through a functional coupling between hippocampal and cortical network activity, how they interact to subserve a transfer of information is less clear. To provide new insight regarding the interaction of HPC and NC during sleep, we have combined novel imaging technologies with genetic, molecular and electrophysiological techniques to interrogate the cortical circuits at the level of individual synapses and function with millisecond temporal resolution across the entire cortex with information from the hippocampus. Further, I will discuss our effort to monitor how HPC output to NC is altered in the mouse model of Alzheimer’s disease.