NEURBIO 230: Epigenetics in Health and Disease is taught once every two years in Fall Quarter by Professors Marcelo Wood and Kyoko Yokomori.
Dr. Marcelo Wood
Dr. Kyoko Yokomori
Prerequisite: MOL BIO 203 or MOL BIO 204 or NEURBIO 206
Same as BIOCHEM 225.
Restriction: Graduate students only.
Taught once every two years in Fall Quarter. The last time NEURBIO 230 was taught was in Fall 2019.
Course Objective:
Focuses on the role of chromatin/nuclear structure organization (histone and DNA modification, chromatin remodeling, higher order chromatin structure and nuclear organization) on gene regulation, DNA replication and repair, relevant to development, metabolism, learning and memory, and human disease.
Sample Syllabus
| # | Topic |
| Part I: Basic Concept of Epigenetics | |
| 1 | Introduction |
| 2 | Nuclear Organization |
| 3 | Histone Modifying Enzymes |
| 4 | Cutting Edge Techniques and Reagents to Study Epigenetics |
| 5 | Special Lecture |
| Part II: Chromatin Regulation in Development | |
| 6 | Chromatin Regulation in Development and Stem Cells |
| 7 | Discussion |
| 8 | Chromatin Regulation in Filament Development |
| 9 | Discussion |
| Part III: Chromatin Regulation in Human Health and Disease | |
| 10 | Seminar |
| 11 | Histone Modifying Enzymes in Learning and Memory |
| 12 | Discussion |
| 13 | Epigenetics and Metabolism |
| 14 | Discussion |
| 15 | The Role of Histone Modifying Enzymes in Addiction |
| 16 | Discussion |
| 17 | Epigenetic Abnormality in Human Disorders I |
| 18 | Discussion |
| 19 | Epigenetics Day |
| 20 | Discussion |