N151: Neurobiology of Aging is taught Winter Quarter by Professor Carl W. Cotman.

Carl-Cotman

Dr. Carl W. Cotman

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Prerequisite: BIO SCI N110

Course Objective:

Multidisciplinary overview of the functional capacity of the aging brain, its structural changes and the mechanisms underlying function and structure. Emphasis will be on successful brain aging and those mechanisms which lead to the development of Alzheimer’s disease.

Sample Syllabus:

# Topic
1 Introduction
2

Principles of Good Experimental Design

Optimizing Your Diet
3 Overview of Alzheimer’s Disease and Its Impact on the US and the World
4  Overview of Alzheimer’s Disease and Its Impact on the US and the World
5 Brain Pathology in Alzheimer’s Disease – Review of Papers
6 The Aging Cortical Synapse: Hallmarks and Implications for Cognitive Decline
7

Neurobiology of Exercise

Physical Activity, BDNF, and Brain Health
8 Propagation of Brain Pathology Via Prion-Like Mechanisms
9 Learning, Long-Term Potentiation and Gender
10 Learning, Long-Term Potentiation and Gender
11 Lifestyles and Multidomain Interventions in Elderly Subjects
12 Manipulating the Human Microbiome to Manage Disease
13 MIDTERM
14 Omics Approaches
15 Immunization and Other Therapeutic Strategies
16 Peripheral and Central Interactions and Parabiosis
17 DNA Damage and the Emergence of Brain Pathology
18 DNA Damage and the Emergence of Brain Pathology
19 Class Presentations and Discussion
20 Class Presentations and Discussion
21 Class Presentations and Discussion
FINAL