N154: Molecular Neurobiology is taught in the Spring Quarter by Professor Katumi Sumikawa.

sumikawa (from Frank-laferlas-imac)

Dr. Katumi Sumikawa

Prerequisite: BIO SCI 99

Course Objective:

Nature and actions of genes/gene products that regulate the functioning of the nervous system and its interaction with muscles. Topics include neural control of gene expression; genetics and molecular biology of neural and neuromuscular diseases; gene therapies for neural disorders.

Sample Syllabus:

#Topic
Section 1: Molecules Involved in Synaptic Transmission
1-5

Introduction

Synthesis, Storage, and Removal of Neurotransmitters

Neurotransmitter Transporters

Release of Neurotransmitters

6Discussion/Review – Objectives: To understand the Basic Molecular Mechanisms of Synaptic Transmission
7EXAM 1
Section 2: Molecules Involved in Neuronal Signaling
8-12

Ligand-Gated Neurotransmitter Receptors

G Protein-Coupled Neurotransmitter Receptors

G Proteins and Effector Proteins

Second Messengers

13Discussion/Review – Objectives: To Understand the Basic Molecular Mechanisms Controlling Neuronal Signaling
14EXAM 2
Section 3: Mechanisms Underlying Synaptic Plasticity
15-18

Protein Kinases

Protein Phosphorylation in Neuronal Signaling

Long-Term Potentiation, a Cellular Model of Learning and Memory

Long-Term Depression

19Discussion/Review – Objectives: To Understand the Basic Molecular Mechanisms Underlying Learning and Memory
20EXAM 3/FINAL EXAM