N154: Molecular Neurobiology is taught in the Spring Quarter by Professor Katumi Sumikawa.
Dr. Katumi Sumikawa
Prerequisite: BIO SCI 99
Course Objective:
Nature and actions of genes/gene products that regulate the functioning of the nervous system and its interaction with muscles. Topics include neural control of gene expression; genetics and molecular biology of neural and neuromuscular diseases; gene therapies for neural disorders.
Sample Syllabus:
| # | Topic |
| Section 1: Molecules Involved in Synaptic Transmission | |
| 1-5 |
Introduction Synthesis, Storage, and Removal of Neurotransmitters Neurotransmitter Transporters Release of Neurotransmitters |
| 6 | Discussion/Review – Objectives: To understand the Basic Molecular Mechanisms of Synaptic Transmission |
| 7 | EXAM 1 |
| Section 2: Molecules Involved in Neuronal Signaling | |
| 8-12 |
Ligand-Gated Neurotransmitter Receptors G Protein-Coupled Neurotransmitter Receptors G Proteins and Effector Proteins Second Messengers |
| 13 | Discussion/Review – Objectives: To Understand the Basic Molecular Mechanisms Controlling Neuronal Signaling |
| 14 | EXAM 2 |
| Section 3: Mechanisms Underlying Synaptic Plasticity | |
| 15-18 |
Protein Kinases Protein Phosphorylation in Neuronal Signaling Long-Term Potentiation, a Cellular Model of Learning and Memory Long-Term Depression |
| 19 | Discussion/Review – Objectives: To Understand the Basic Molecular Mechanisms Underlying Learning and Memory |
| 20 | EXAM 3/FINAL EXAM |